SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression
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چکیده
منابع مشابه
SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression
Ubiquitination governs oscillation of cyclin-dependent kinase (CDK) activity through a periodic degradation of cyclins for orderly cell cycle progression; however, the mechanism that maintains the constant CDK protein levels throughout the cell cycle remains unclear. Here we show that CDK6 is modified by small ubiquitin-like modifier-1 (SUMO1) in glioblastoma, and that CDK6 SUMOylation stabiliz...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms5234